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UCSF Over 80 Clinic

The staff of the UCSF Over 80 Clinic seek to address the complex dementia care issues commonly seen when caring for the oldest old. This care often requires an in-depth understanding of co-existing non-dementia medical illnesses, medication interactions, and the integrated living environment encountered in care of elders.

The staff of the UCSF Over 80 Clinic seek to address the complex dementia care issues commonly seen when caring for the oldest old. This care often requires an in-depth understanding of co-existing non-dementia medical illnesses, medication interactions, and the integrated living environment encountered in care of elders. In contrast to the clinical priorities for younger patients with cognitive decline, diagnosis is often only a small factor in maximizing outcomes.

Contact Us

For more information about the Neurodegenerative Disease Brain Bank (NDBB) and its tissue sharing procedure, please contact the administrative manager. For questions about the Autopsy Program, please contact the autopsy coordinator.

For more information about the Neurodegenerative Disease Brain Bank (NDBB) and its tissue sharing procedure, please contact the administrative manager at 415-502-7459.

For questions about the Autopsy Program, please contact the autopsy coordinator at 415-476-1681 or autopsy@memory.ucsf.edu.

Neurodegenerative Disease Brain Bank (NDBB) Director
William Seeley, MD
Associate Professor of Neurology
UCSF Memory and Aging Center
415-476-2793
wseeley@memory.ucsf.edu

Brain Donation

Brain donation provides individuals the opportunity to help others affected by dementia by advancing our scientific understanding of neurodegenerative diseases and healthy aging. We honor the gift of donation and treat donors, their bereaved families, and all tissue with care and respect.

Why donate?

Brain donation provides individuals the opportunity to help others affected by dementia by advancing our scientific understanding of neurodegenerative diseases and healthy aging. We honor the gift of donation and treat donors, their bereaved families, and all tissue with care and respect.

Examining the brain after death is currently the only way to obtain a definitive diagnosis of the underlying causes of dementia. A diagnosis of absolute certainty cannot be made by clinical evaluation alone.

Mild Alzheimer's Disease Trial with BMS-241027

BMS-241027, also known as Epothilone D, is a microtubule stabilizing agent that also has effects on tau protein in animal models of Alzheimer’s disease. The purpose of this study is to evaluate whether BMS-241027 is safe and well-tolerated in subjects with Alzheimer’s disease.

Summary

  • Study director: Adam Boxer, MD, PhD
  • Sponsor: Bristol-Myers Squibb, Inc.
  • Recruiting?: Yes
  • Official study title: Study to Evaluate the Safety, Tolerability and the Effect of BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects With Mild Alzheimer's Disease
  • ClinicalTrials.gov identifier: NCT01492374

Prion Research as a Model

Submitted by admin on September 6, 2012 - 6:05pm
Content Link: 
http://www.youtube.com/watch?v=oCBfHHV1Dk8&feature=BFa&list=EC8FCF7487A6825F26
Content Type: 
video

Dr. Michael Geschwind and Dr. Stanley Prusiner share their work on prion disease as a model to hopefully find cures for not only Creutzfeldt-Jakob disease but also Alzheimer's disease, frontotemporal dementia and Parkinson's disease.

What is a prion?

Submitted by admin on September 6, 2012 - 5:37pm
What is a prion? (video)
Content Link: 
http://www.youtube.com/watch?v=w5aAPEYIL9A&feature=relmfu
Content Type: 
video

A prion protein is a naturally occurring protein that can be found throughout our bodies and in high concentrations in the brain.

CJD & Other Prion Disorders

Submitted by admin on September 6, 2012 - 4:27pm
CJD & Other Prion Disorders
Content Link: 
http://www.youtube.com/watch?feature=player_embedded&v=yzDQ8WgFB_U
Content Type: 
video

This clip describes the origins of prion disease and what prions are.

Prion Resource Sharing

The Memory and Aging Center encourages and facilitates research and publications by current and new investigators. We are eager to help generate successful proposals, secure funding and publish study results. Resources are provided solely for use in academic, not-for-profit research at recognized educational institutions.

Academic, not-for-profit investigators can request the following resources from the UCSF Memory and Aging Center (MAC):

  • Subjects for research studies
  • Archived data
  • Imaging data
  • Tissue specimens
  • Video clips of behaviors

For details, please see our Resource Sharing page.

Prion Research Meetings

Scientific and medical meetings provide a forum for new ideas in research or treatment to be presented to colleagues and discussed. There are several meetings focused on prion disease.

Lorne Conference on Protein Structure and Function

  • February 10–14, 2013
  • Lorne, Victoria, Australia

This meeting is held each year in February at Lorne, a scenic beach resort 150 km from Melbourne and attracts approximately 450 protein scientists. The goal of the meeting is to highlight leading edge protein science, irrespective of its focus. The meeting includes oral and poster presentation sessions, a young investigator session, trade workshops, social events and trade displays.

Recent Publications About Prion Disease

To read scientific abstracts and articles, please search PubMed, a service of the National Library of Medicine and the National Institutes of Health or browse our selected list of articles about prion disease.

PubMed is a service of the National Library of Medicine and the National Institutes of Health. It comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

Selected Articles Related to Prion Disease

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