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News & Articles
Prion Topology and Toxicity
Inactivation of mahogunin, an E3 ubiquitin ligase, causes a spongiform encephalopathy resembling prion disease. Chakrabarti and Hegde (2009) now report that prion proteins with aberrant topologies inactivate mahogunin, providing a plausible explanation for certain aspects of prion pathology.
Citation: Aguzzi A, Steele AD. Prion Topology and Toxicity. Cell. 2009;137:994-996.
full text article from publisher:
Volume:
137
Publisher:
Elsevier Inc.
Source:
Cell
Publication date:
06/12/2009