Help improve the diagnosis of CJD Learn more.

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Help improve the diagnosis of CJD Learn more

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Diagnosing CJD

  • Differential Diagnosis

    A diagnosis of probable CJD requires an extensive exclusionary work up. The mnemonic device “VITAMINS” highlights other potential causes of rapidly progressive dementias:

    • Vascular
    • Infectious
    • Toxic-metabolic
    • Autoimmune
    • Metastases/neoplasm
    • Iatrogenic
    • Neurodegenerative
    • Systemic

    It is important to rule out these conditions before confirming prion disease.

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  • Confirming CJD

    Diagnostic criteria to confirm a diagnosis of definite, probable and possible CJD for each form of CJD have been created. These criteria are constantly revised as research and experience provide more data. California physicians should note that CJD is now a reportable disease.

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    Related Articles: 
    CJD Terminology
    Genetics
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